Artificial intelligence is transforming industries at a rapid pace, but in clinical research, especially neurology, adoption has been slower. The stakes are high: complex imaging data, regulatory expectations, and patient needs demand solutions that are rigorous and reliable.
Few people are better positioned to speak on this challenge than Dr. John E. Kelly III. Widely recognized as the “father of IBM Watson”, Dr. Kelly has spent decades at the forefront of AI innovation. Today, he is one of the leading voices on how AI can responsibly support healthcare and clinical trials.
In this interview, Dr. Kelly shares his perspective on the opportunities, obstacles, and future of AI in neurological research and clinical trials, and the lessons that remain relevant for sponsors, researchers, and innovators alike.
Q1. You’ve witnessed AI evolve from concept to real-world applications across industries. How do you see that journey shaping its role in clinical research, particularly in neurology?
Dr. Kelly: AI has gone from being an abstract concept to becoming a practical tool that touches everyday life. In clinical research — especially neurology — its potential is extraordinary. We can now process vast volumes of imaging and clinical data that were previously too complex to analyze. This capability allows us to identify patterns, design more effective trials, and ultimately generate insights that improve patient outcomes.
Q2. Despite strong momentum, many researchers still hesitate to fully integrate AI into trials. From your perspective, what’s holding the field back — and what will it take to overcome those barriers?
Dr. Kelly: Trust, data, and culture are the main barriers. Researchers and regulators need confidence that AI systems are scientifically valid and explainable. Data is often fragmented or non-standardized, which reduces reliability. And culturally, the introduction of AI requires shifts in established workflows, which can be uncomfortable. Overcoming these challenges will take rigorous validation, open standards, and collaboration between academia, industry, and regulators.
This theme of trust and adaptation leads naturally to the lessons learned from Watson, one of the earliest large-scale healthcare AI projects.
Q3. IBM Watson was a landmark moment for AI in healthcare. Looking back, what lessons from that experience remain most relevant for today’s researchers and trial sponsors?
Dr. Kelly: Watson demonstrated both the promise and the hurdles of AI in healthcare. The lessons remain clear: AI must integrate seamlessly into existing systems; usability is critical if clinicians and researchers are to adopt it; and transparency in how AI reaches conclusions is non-negotiable. These principles are timeless, and they remain essential as we push AI further into clinical research.
Q4. AI can only be as good as the data behind it. How do you see data quality, standardization, and collaboration shaping the success of AI-enabled trials?
Dr. Kelly: Data is the foundation of everything. Without quality and harmonization, AI cannot produce results that are reliable or reproducible. This is why global standards and harmonization across sites are essential. Collaboration is also key — no single organization can solve this alone. When institutions share data responsibly and agree on frameworks, AI has the potential to accelerate progress across the entire research ecosystem. It’s also why next-generation, cloud-based AI platforms like QMENTA are so critical to success — they provide the infrastructure to ensure data quality, standardization, and scalability across trials.
Q5. Based on what you’ve seen, what does QMENTA offer to address these challenges?
Dr. Kelly: What stands out about QMENTA is how it combines scientific depth with operational practicality. The platform enables researchers to manage complex imaging datasets securely, harmonize data across multiple sites, and apply advanced AI analytics at scale. That combination — compliance, quality, and accessibility — is exactly what the field needs to move AI from potential to practice. QMENTA is helping create the kind of trusted environment where AI can accelerate clinical development while maintaining scientific rigor.
Q6. If you look ahead five to ten years, what breakthroughs do you expect AI will bring to clinical research — and what impact could that have on patients?
Dr. Kelly: I see AI transforming every phase of the clinical trial process. Patient selection will be more precise, endpoints will be more sensitive, and imaging will play a stronger role in linking biology to outcomes. The trials of the future will be faster, more efficient, and more informative. For patients, this means earlier access to therapies and a higher likelihood that those therapies succeed once they reach clinical practice.
Dr. Kelly’s insights make one point clear: AI is not simply a tool — it is a catalyst for more rigorous, collaborative, and patient-centered research. The opportunity is here, but realizing it depends on trust, high-quality data, and cross-sector collaboration.
The future of clinical research lies at the intersection of visionary insight and practical implementation. By bringing these together, the industry can accelerate innovation — and deliver new therapies to patients with greater speed, clarity, and confidence.
The questions Dr. Kelly raises — around trust, data quality, and collaboration — are the very challenges shaping the future of clinical trials. At QMENTA, we work side by side with research teams to tackle these issues in practice. Our purpose is to empower the world’s leading innovators to accelerate the discovery of cures for brain diseases by removing the complexity of medical imaging data.
If you’d like to explore how we can empower your studies approach could support your own studies, Schedule a 30-minute technical demonstration .
Our team is ready to connect, understand your imaging challenges, and help you reach your research goals. We’ll show how our platform can adapt to your specific requirements.