Whole Brain Volume, Grey Matter Volume & Cortical Thickness
Whole brain volume is the most commonly used imaging endpoint in clinical trials in Alzheimer’s(16). Additionally, it has been shown in studies that volume/thickness changes or abnormal values for determined areas can be a good biomarker for the detection of the disease and estimation of its progression.(17,18,19) QMENTA’s gray matter volumetry tools allow for quantification of region-specific gray matter volume for each patient timepoint using processing tools such as FreeSurfer, ANTs and SIENAX. The QMENTA Platform’s data management allows longitudinal assessment of gray matter atrophy.
Diffusion Measures on Main Fiber Bundles
Diffusion-weighted imaging quantification has been identified as a promising biomarker in Alzheimer’s disease, revealing white matter alteration and enabling neurobiologically meaningful prognosis and outcomes.(20,21) QMENTA offers a suite of automated tools for analysis of diffusion-weighted imaging analysis including fascicle specific diffusion measurements.
Patterns of Whole Brain Structural Connectivity
Connectomics allows the study of structural brain connectivity, both at the level of individual connections between relevant areas and through graph-measures to characterize whole-brain connectivity. It can be used to research the possible impact of these diseases on brain connectivity. (22) The QMENTA platform provides fully automatic connectome analysis tools.
Hippocampal atrophy is the most important imaging-derived biomarker in Alzheimer’s disease, commonly used in both research and clinical trials.(14) The QMENTA platform offers tools for volumetric quantification of hippocampal subfields, including hi-resolution hippocampal image quantification.
Ventricular volume is a commonly used imaging endpoint in clinical trials for Alzheimer’s therapies.(16) QMENTA’s volumetric tools provide ventricular volume quantification.
Basal Ganglia Volumetry
Aside from the whole brain and the hippocampus, regions of the basal ganglia are also found to exhibit atrophy in the progression of Alzheimer’s.(15) QMENTA offers tools for volumetric quantification of basal ganglia structures.