Imaging Biomarkers

Parkinson’s Disease

Identification of atrophy at specific parts of the brain gives valuable insight for the diagnosis of Parkinson's and the differentiation of its variants.


< Back to Biomarkers

Gray Matter Volume and Thickness Quantification

Particular brain structure atrophy patterns appear in longitudinal MRI specific to Parkinsonian variants such as progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), thus identifying cortical atrophy measurements from T1 weighted MRI is as a promising potential biomarker for Parkinson’ disease (PD)(9,10). The QMENTA platform’s gray matter volumetry tools allow for quantification of region-specific gray matter volume for each patient timepoint using processing tools such as FreeSurfer, ANTs and SIENAX. The platform’s data management allows longitudinal assessment of gray matter atrophy.

Hippocampal and Basal Ganglia Volumetry

Hippocampal and striatal volumetric reductions have been observed in PD patients.(8) The QMENTA platform offers tools for volumetric quantification of basal ganglia structures and hippocampal subfields, including hi-resolution hippocampal image quantification.

Interested in our Parkinson's biomarkers?

Talk to our team to learn more.


8. Saeed, Usman, et al. "Imaging biomarkers in Parkinson’s disease and Parkinsonian syndromes: current and emerging concepts." Translational neurodegeneration 6.1 (2017): 8.
9. Claassen, Daniel O., et al. "Cortical asymmetry in Parkinson's disease: early susceptibility of the left hemisphere." Brain and behavior 6.12 (2016): e00573.
10. Hwang, Kristy S., et al. "Mapping cortical atrophy in Parkinson's disease patients with dementia." Journal of Parkinson's disease 3.1 (2013): 69-76.